Table 1.
Candidate genes and SNPs, NCI-SEER NHL Survival Study
| Gene | Name | Location | SNP rs no. |
|---|---|---|---|
| CARD15 | Caspase recruitment domain family, member 15 | 16q12 | rs2066842,* rs2066844,* rs2066847 |
| CCR2 | Chemokine, CC motif, receptor 2 | 3p21 | rs1799864 |
| CCR5 | Chemokine, CC motif, receptor 5 | 3p21 | rs333 |
| CTLA4 | Cytotoxic T lymphocyte-associated 4 | 2q33 | rs231775 |
| CSF3 | Colony stimulating factor 3 (granulocyte) | 17q11.2-q12 | rs25645* |
| CX3CR1 | Chemokine, CXC motif | 3p21 | rs3732379* |
| CXCL12 | Chemokine, CXC motif, ligand 12 | 10q11.1 | rs1801157 |
| FCGR2A | Receptor for Fc fragment of IgG, low affinity IIa (CD32) | 1q21-q23 | rs1801274 |
| ICAM1 | Intercellular adhesion molecule 1 (CD54) | 19p13.3-p13.2 | rs5491 |
| INFA1 | Interferonα1 | 9p22 | rs1758566* |
| IFNG | Interferonγ | 21q14 | rs1861494, rs2069705 |
| IFNGR1 | Interferonγ receptor 1 | 6q23-q24 | rs3799488* |
| IFNGR2 | Interferonγ receptor 2 | 21q22.11 | rs9808753 |
| IL1A | Interleukin 1α | 2q13 | rs17561, rs1800587 |
| IL1B | Interleukin 1β | 2q14 | rs16944, rs1143627, rs1143634 |
| IL1RN | Interleukin 1 receptor antagonist | 2q14.2 | rs454078 |
| IL2 | Interleukin 2 | 4q26-q27 | rs2069762 |
| IL3 | Interleukin 3 | 5q31.1 | rs40401* |
| IL4 | Interleukin 4 | 5q31.1 | rs2070874, rs2243248, rs2243250 |
| IL4R | Interleukin 4 receptor | 16p12.1-p11.2 | rs2107356 |
| IL5 | Interleukin 5 | 5q31.1 | rs2069807, rs2069812, rs2069818* |
| IL6 | Interleukin 6 | 7p15.3 | rs1800795, rs1800797 |
| IL7R | Interleukin 7 receptor (CD127) | 5p13 | rs1494555* |
| IL8 | Interleukin 8 | 4q12-q13 | rs4073, rs2227307, rs2227306 |
| IL8RB | Interleukin 8 receptor β | 2q35 | rs1126579, rs1126580, rs2230054* |
| IL9 | Interleukin 9 | 5q31.1 | rs1799962* |
| IL9R | Interleukin 9 receptor | Xq28 or Yq12 | rs6522* |
| IL10 | Interleukin 10 | 1q31-q32 | rs1800871, rs1800872, rs1800896, rs1800890 |
| IL10RA | Interleukin 10 receptor α | 11q23.3 | rs9610 |
| IL12A | Interleukin 12 α | 3q25.33 | rs568408 |
| IL12B | Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 5q33.3 | rs3212227 |
| IL13 | Interleukin 13 | 5q23.3 | rs20541, rs1800925 |
| IL15 | Interleukin 15 | 4q31.21 | rs10833 |
| IL15RA | Interleukin 15 receptor α | 10p15.1 | rs2296135 |
| IL16 | Interleukin 16 | 15q25.1 | rs859, rs11325 |
| JAK3 | Janus kinase 3 | 19p13.1 | rs3008,* rs3212713* |
| LTA | Lymphotoxin-α | 6p21.3 | rs909253, rs2239704 |
| MBL2 | Mannose-binding lectin (protein C) 2, soluble | 10q11.2-q21 | rs7095891,* rs11595876,* rs10824792,* rs2083771* |
| SELE | Selectin E | 1q22-q25 | rs5361* |
| STAT1 | Signal transducer and activator of transcription 1 | 2q32.2-q32.3 | rs2066804* |
| TLR4 | Toll-like receptor 4 | 9q32-q33 | rs4986790 |
| TNF | Tumor necrosis factor | 6p21.3 | rs1800629, rs361525, rs1799724, rs1800630 |
| TNFRSF10A | Tumor necrosis factor receptor superfamily, 10a | 8p21 | rs20577* |
| VCAM1 | Vascular cell adhesion molecule 1 | 1p32-p31 | rs1041163, rs3176879 |
*
Genotyped in blood-based samples only.