Table 3.
Haplotype analyses
| Genes | SNPs in haplotype | Haplotype, % | HR* | 95% CI | P† | |||
|---|---|---|---|---|---|---|---|---|
| TNF/LTA | rs1800629 TNF G-308A | rs909253 LTA A252G | ||||||
| 1 | G | A | 62 | 1.00 | reference | |||
| 2 | A | A | < 1 | |||||
| 3 | G | G | 19 | 1.05 | (0.74, 1.50) | .8 | ||
| 4 | A | G | 19 | 1.36 | (0.96, 1.94) | .09 | ||
| IL10 | rs1800871 C-819T | rs1800872 C-592A | rs1800896 A-1082G | rs1800890 T-3575A | ||||
| 1 | A | T | 55 | 1.00 | reference | |||
| 2 | G | A | 38 | 1.21 | (0.89, 1.65) | .22 | ||
| 3 | G | T | 7 | 1.82 | (1.08, 3.07) | .02 | ||
| 4 | A | A | < 1 | |||||
| IL10 | rs1800871 C-819T | rs1800872 C-592A | rs1800896 A-1082G | rs1800890 T-3575A | ||||
| 1 | C | C | A | T | 28 | 1.00 | reference | |
| 2 | C | C | G | A | 39 | 1.42 | (0.94, 2.14) | .10 |
| 3 | T | A | A | T | 26 | 1.59 | (1.01, 2.50) | .04 |
| 4 | C | C | G | T | 7 | 2.44 | (1.34, 4.44) | .003 |
*
Hazard ratio (HR) adjusted for age and clinical and demographic factors.
†
Global P values are P = .23 for the TNF/LTA haplotype, P = .07 for the IL10 2-SNP haplotype, and P = .03 for the IL10 4-SNP haplotype. Global P value is testing the association of all observed haplotypes on a gene with survival.