Table 4.

Univariate and multivariate Cox models for the 4 SNP risk score

No. of deleterious genotypes*	n	Percent dead	Univariate model		Multivariate model†
			HR	95% CI	HR	95% CI
0,1	74	12.2	1.00	(reference)	1.00	(reference)
2,3	247	26.7	2.47	1.23-4.96	2.76	1.37-5.56
4	44	47.7	5.63	2.57-12.3	6.77	3.05-15.0
Continuous			1.56	1.26-1.94	1.65	1.32-2.05

P values for trend test are P = 2.8 × 10⁻⁵ and P = 3.7 × 10⁻⁶ for univariate and multivariate models, respectively.

^*Deleterious genotypes from IL1A (rs1800587), IL8RB (rs1126580), IL4R (rs2107356), and TNF (rs1800629), as coded in Table 2.

^†Adjusted for age and clinical and demographic factors.