Figure 4.

Time courses of patients who transitioned above or below a cardiac R2* of 50 Hz. The time courses of the patients with increasing and decreasing cardiac R2* are shown in the top and bottom panels, respectively. Cardiac R2* (equal to 1000/T2*) is on the vertical axis in log scale; HIC (calculated using liver R2 and R2*) is on the horizontal axis. First and last MRI measurements are denoted by a filled circle and an “x,” respectively. These graphs represent 8 patients with 9 transitions. The patient who transitioned above and below an R2* of 50 Hz during the given time is shown in both panels (*). In each panel, only the relevant part of this time course is colored black; the unrelated portion is gray. The arrows indicate the direction of cardiac iron (increasing R2* or decreasing R2*).