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. 2008 Jun 27;112(7):2979–2989. doi: 10.1182/blood-2008-03-140830

Table 3.

Results of univariate and multivariate analyses of graft and patient factors influencing platelet engraftment

Variable Univariate analysis (includes only significant variables)
Multivariate analysis (includes only significant variables)
Favorable in multivariate analysis
Hazard ratio 95% CI P Hazard ratio 95% CI P
Age, y
    Older than 2 0.46 0.31-0.67 < .001 0.57 0.38-0.85 < .01 Patients ≤ 2 y
    2 or younger 1.00 1.00
Recipient sex
    Male 0.64 0.45-0.93 .02 0.65 0.44-0.95 .03 Female recipients
    Female 1.00 1.00
Cryopreserved cell dose, × 107/kg
    More than 9.7 1.58 1.10-2.28 .01
    9.7 or less 1.00
Reinfused cell dose, × 107/kg
    More than 7.6 1.85 1.28-2.66 < .01
    7.6 or less 1.00
Reinfused CD34, × 105/kg
    More than 2.1 1.49 1.04-2.15 .03
    2.1 or less 1.00
Reinfused CFU, × 104/kg
    More than 5.7 3.42 2.33-5.02 < .001 2.81 1.87-4.21 < .001 Higher CFU infused
    5.7 or less 1.00 1.00
Reinfused CD3, × 106/kg
    More than 14.2 1.45 1.01-2.09 .05
    14.2 or less 1.00
ABO match
    Mismatched 1.47 1.02-2.13 .04
    Matched 1.00

Variables not found to be statistically significant in univariate analysis include performance status (< 80, ≥ 80), unit sex, sex matching (recipient/unit), date of transplantation (after 1/1/2001, before 1/1/2001), HLA match (3/6 and 4/6 versus 5/6 and 6/6), recipient ethnicity, unit ethnicity, ethnicity matching (recipient/unit), recipient CMV status, and recipient weight (<12 kg, ≥ 12 kg).