Table 5.

Result of univariate and multivariate analyses of graft and patient factors on overall survival (OS)

OS Variable	Univariate analysis (includes only significant variables)			Multivariate analysis (includes only significant variables)			Favorable in multivariate analysis
	Hazard ratio	95% CI	P	Hazard ratio	95% CI	P
Performance status
Less than 80	3.72	2.17-6.36	< .001	3.49	2.00-6.07	< .001	Lansky score 80-100
80 or more	1.00			1.00
Reinfused CFUs, × 104/kg
More than 5.7	0.47	0.28-0.80	.005	0.53	0.31-0.91	.02	CFUs > 5.7
5.7 or less	1.00			1.00
HLA match
5/6 or 6/6	0.62	0.37-1.04	.07
3/6 or 4/6	1.00
Ethnicity matching
Mismatched	1.70	0.93-3.10	.09	1.84	1.00-3.38	.05	Matched ethnicity
Matched	1.00			1.00

Variables not found to be statistically significant in univariate analysis include performance status (< 80, ≥ 80), age (> 2 years, ≤ 2 years), recipient sex, unit sex, sex matching (recipient/unit), cryopreserved cell dose × 10⁷/kg (> 9.7, ≤ 9.7), reinfused cell dose × 10⁷/kg (> 7.6, ≤ 7.6), reinfused CD34 × 10⁵/kg (> 2.1, ≤ 2.1), reinfused CFUs × 10⁴/kg (> 5.7, ≤ 5.7), reinfused CD3 × 10⁶/kg (> 14.2, ≤ 14.2), date of transplantation (after 1/1/2001, before 1/1/2001), recipient ethnicity, unit ethnicity, ethnicity matching (recipient/unit), ABO match, HLA match (5/6 and 6/6, 3/6 and 4/6), recipient CMV serostatus, and recipient weight (< 12 kg, ≥ 12 kg).