Table 2.

Contingency table underlying the guilt-by-association algorithm

Disease Associated?	Number of Connections	% Disease-associated genes among interactors
		≤ 75	> 75
Yes	≤ 12	3,112	1,907
	> 12	481	651
No	≤ 12	7,853	705
	> 12	229	112

Number of disease- and non-disease-associated genes by thresholds on number of connections and percentage of disease-associated genes among interactors. The thresholds are obtained from exploring disease-associated genes and correspond to the average number of connections (12) among disease-associated genes and the average proportion of disease-associated genes (75%) among their interactors. The 112 non-disease-associated genes (bottom right cell) form the basis of the newly reported disease-associated genes [see Additional file 2].