Table 2.
Genes down-regulated following CPT treatment in both U87-MG and DBTRG-05
| GeneName | Description |
| DNA metabolism and replication | |
| ADK | Adenosine kinase |
| CDC45L | Cell division cycle 45 like |
| DTYMK | Deoxythymidylate kinase (dTMP kinase) |
| FEN1 | Flap structure specific endonuclease 1 |
| H2AFZ | H2A histone family Z |
| KIAA0101 | The PCNA-associated factor KIAA0101/p15(PAF) |
| MCM2 | Mini chromosome maintenance deficient 2 |
| MCM3 | Minichromosome maintenance deficient 3 |
| MCM7 | Minichromosome maintenance deficient 7 |
| RRM1 | Ribonucleotide reductase M1 subunit, |
| RRM2 | Ribonucleotide reductase subunit M2, |
| TYMS | Thymidylate synthetase |
| UHRF1 | Nuclear protein 95 |
| Cell cycle and mitosis | |
| ANKT | nucleolar and spindle associated protein 1 |
| BIRC5 | Survivin |
| CCNA2 | Cyclin A2 |
| CDC2 | Cell division cycle 2 |
| CDCA5 | cell division cycle associated 5 |
| KNSL6 | Mitotic centromere-associated kinesin (kinesin-like 6) |
| PRC1 | Protein regulator of cytokinesis 1 |
| STMN1 | Stathmin 1 (oncoprotein 18) |
| TOPK | PDZ-binding kinase |
| UBE2C | Ubiquitin-conjugating enzyme E2C |
| ZWINT | ZW10 interactor |
| Miscellaneous | |
| DKFZp762E1312 | Protein of unknown function |
| I_932099 | Protein with high similarity to human HNRPA1, |
| ID1 | Inhibitor of DNA binding 1 |
| KPNA2 | Karyopherin alpha 2 (importin alpha 1), |
| LOXL2 | Lysyl oxidase-like 2 |
| p100 | EBNA-2 co-activator (100 kD) |
| SPOCK | Testican |
| TSSC3 | Tumor suppressing subtransferable candidate 3 |
| UBE2T | ubiquitin-conjugating enzyme E2T |