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. 1999 Oct;10(10):3125–3136. doi: 10.1091/mbc.10.10.3125

Figure 4.

Figure 4

Effects of SIR2 deletion on life-span and ERC generation. (A) Survival curves of wild-type control (YPK9), sir2 (YAB11), rpd3Δ (YAB12), and rpd3Δ sir2 (YAB13). Mean life-span (and the number of cells analyzed) was 18.7 (39) for the wild-type, 25.8 (40) for the rpd3Δ, 12.5 (39) for the sir2, and 11.6 (39) for the rpd3Δ sir2 strains, respectively. The rpd3Δ, sir2, and rpd3Δ sir2 strain life-spans differed from wild-type (P ≪ 0.0001). There is no statistical difference between the life-spans of the sir2 and rpd3Δ sir2 strains (P = 0.8). (B) ERC generation in the wild-type and sir2 strains used in A. The large arrowhead indicates genomic rDNA, whereas the smaller arrows point to extrachromosomal rDNA.