Table 3.
Effect of deletion of RPD3, HDA1, and SIR3 on telomeric silencing
| Strain (all URA3::TelVR) | No. of cultures | Frequency of 5-fluoroorotic acid-resistant colonies (mean ± SD) | Relative frequency |
|---|---|---|---|
| YDS21U (control) | 8 | 0.049 ± 0.046 | 1.00 |
| YSK831 (hda1Δ) | 8 | 0.210 ± 0.063** | 4.29 |
| YSK830 (rpd3Δ) | 8 | 0.631 ± 0.147** | 12.88 |
| YSK829 (sir3Δ) | 7 | 9.27 ± 7.47 × 10−8 | 1.89 × 10−6 |
| YSK833 (hda1Δ sir3Δ) | 8 | 12.84 ± 18.07 × 10−8 | 2.62 × 10−6 |
| YSK832 (rpd3Δ sir3Δ) | 8 | 34.81 ± 55.04 × 10−8* | 7.10 × 10−6 |
*
P < 0.05 compared with the sir3Δ strain.
**
P < 0.01 compared with the control.