Table 1.

Studies on hypothermia in malignant hemispheric infarction

Authors	Number	Target temperature	Time to induction of hypothermia (hours)	Duration of hypothermia (hours)
Schwab et al., 1998 [95]	25	33°C (external cooling)	4–24, mean 14 ± 7	48–72
Schwab et al., 2001 [134]	50	32°C–33°C (external cooling)	4–75, mean 22 ± 9	24–72
Georgiadis et al., 2001 [99]	6	33°C (endovascular cooling)	12–58, mean 28 ± 17	48–78
Georgiadis et al., 2002 [124]	19	33°C (n = 8 endovascular cooling; n = 11 external cooling)	18–24, mean 24	24–116
Milhaud et al., 2005 [94]	12	32°C–33°C (external cooling)	4–24, mean 11 ± 7	120–504