Table 6.
Functional outcome data in patients with malignant middle cerebral artery infarction: studies with comparative data on conservative treatment versus decompressive surgery
| Authors | Patients treated with conservative treatment | Patients treated with decompression | Mean age (years) | Dominant/nondominant hemisphere | + ACA and/or PCA | Mean time to surgery (hours) | Mean time to follow-up (months) | Independent outcome | Mild to moderate disability | Severe disability | Death |
| Delashaw et al., 1990 [118] | 4 | NA | 100%/0% | NA | NA | NA | 0% | 0% | 0% | 100% | |
| 9 | 57 | 0%/100% | 56% | NA | 15 | 22% | 22% | 44% | 11% | ||
| Steiger 1991 [119] | 7 | NA | NA | NA | NA | 6 | 0% | 0% | 0% | 100% | |
| 8 | NA | NA | NA | NA | 6 | 75% | 75% | 75% | 25% | ||
| Rieke et al., 1995 [77] | 55 | 56 | 62%/38% | 22% | NA | 1 | 22% | 22% | 22% | 78% | |
| Hacke et al., 1996 [3] | 63 | 50 | 17%/83% | 35% | 30 | 3 | 2% | 40% | 33% | 25% | |
| Wirtz et al., 1997 [104] | |||||||||||
| Schwab et al., 1998 [109] | |||||||||||
| Mori et al., 2001 [120] | 21 | 72 | 52%/48% | 33% | NA | 6 | 5% | 0% | 24% | 71% | |
| Mori et al., 2004 [111] | 50 | 65 | 26%/74% | 36% | 63 | 6 | 10% | 10% | 56% | 24% | |
| Kuroki et al., 2001 [121] | 7 | 80 | NA | NA | NA | NA | 14% | 14% | 14% | 86% | |
| 8 | 72 | NA | NA | NA | NA | 87% | 87% | 87% | 13% | ||
| Holtkamp et al., 2001 [114] | 12 | 73 | 83%/17% | 67% | NA | 9 | 0% | 0% | 17% | 83% | |
| 12 | 65 | 25%/75% | 42% | 42 | 5 | 0% | 0% | 67% | 33% | ||
| Cho et al., 2003 [115] | 10 | 64 | 60%/40% | 50% | NA | 6 | 20% | 20% | 20% | 80% | |
| 42 | 63 | 52%/48% | 38% | 50 | 6 | 71% | 71% | 71% | 29% | ||
| Maramattom et al., 2004 [116] | 10 | 63 | 40%/60% | 0% | NA | 1 | 0% | 10% | 30% | 60% | |
| 14 | 55 | 22%/78% | 71% | 36 | 1 | 0% | 38% | 63% | 0% | ||
| Yang et al., 2005 [122] | 14 | 66 | 43%/57% | 57% | NA | 3 | 0% | 0% | 36% | 64% | |
| 10 | 59 | 30%/70% | 60% | 62 | 3 | 10% | 30% | 50% | 10% | ||
| Wang et al., 2006 [117] | 41 | 67 | 56%/44% | NA | NA | 6 | 0% | 25% | 54% | 22% | |
| 21 | 62 | 38%/62% | NA | 48 | 6 | 0% | 14% | 57% | 29% | ||
| Authors | Patients treated with hypothermia | Patients treated with decompression | Mean age (years) | Dominant/nondominant hemisphere | + ACA and/or PCA | Mean time to surgery (hours) | Mean time to follow-up (months) | Independent outcome | Mild to moderate disability | Severe disability | Death |
| Georgiadis et al., 2002 [124] | 19 | 56 | 100%/0% | 26% | NA | NA | NA | NA | NA | 47% | |
| 17 | 52 | 0%/100% | 24% | 30 | NA | NA | NA | NA | 12% | ||
| Authors | Patients treated with decompression + hypothermia | Patients treated with decompression | Mean Age (years) | Dominant/nondominant hemisphere | + ACA and/or PCA | Mean time to surgery (hours) | Mean time to follow-up (months) | Independent outcome | Mild to moderate disability | Severe disability | Death |
| Els et al., 2006 [125] | 12 | 49 | NA | NA | 15 | 6 | 92% (median mRS 2) | 8% | |||
| 13 | 49 | NA | NA | 15 | 6 | 88% (median mRS 3) | 12% | ||||
Functional outcome was classified as described in Table 2. ACA, anterior cerebral artery; NA, not available; PCA, posterior cerebral artery.