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. 2008 Sep 29;205(10):2191–2198. doi: 10.1084/jem.20080720

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© 2008 Zaph et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 5. — IL-25 limits accessory cell-derived IL-23 independently of STAT6. (A) Increased expression of Il23a and Il12b by CD11b⁺ cells isolated from the large intestinal LP of GF mice. (B–F) Expression of mRNA for Il23a (B), Il12a (C), Tgfb (D), Il6 (E), and Il10 (F) in macrophages 4 h after stimulation with LPS in the absence or presence of IL-25 was analyzed by quantitative real-time PCR. Results are from four experiments. (G) mRNA expression of IL-23p19 (Il23a) in WT or Stat6^−/− macrophages was analyzed by real-time PCR after stimulation with media alone, LPS, or LPS and IL-25. Results are representative of two experiments. *, P < 0.05. Error bars indicate the SEM.