Fig. 9. Proposed biosynthetic pathway for L. interrogans lipid A.
Highly significant orthologs of all of the indicated enzymes (2) are encoded in the L. interrogans serovar Lai genome (13). The methyl transferase responsible for the formation of the unusual 1-methylphosphate group of L. interrogans lipid A utilizes S-adenosyl-methionine as the donor (85).