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. Author manuscript; available in PMC: 2009 Sep 15.
Published in final edited form as: J Immunol. 2008 Sep 15;181(6):4072–4079. doi: 10.4049/jimmunol.181.6.4072

Figure 6. Depletion of CD4+ T cells ameliorates disease in vivo.

Figure 6

To determine if the disease process could be abrogated in vivo, neutralizing CD4 antibody was administered via intraperitoneal injection. Aire-deficient animals on the NOD background were treated with 500 micrograms of anti-CD4 (GK1.5) or isotype control once a week starting at 21 days post-birth. Animals were sacrificed at 49 days of age and disease was evaluated by histological analysis. Average histological score for all the organs (A). Representative images of the histology from the eye and lung (B), arrow indicates the immune infiltrates.