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Binding scheme for a sequential mechanism. In this case, A represents dUMP and B represents CH2H4folate. The relevant steps from Scheme 1 are presented in parenthesis. Rate constants that are isotopically sensitive in the proton abstraction experiments (using labeled dUMP) are marked with * and the one that is isotopically sensitive in the hydride transfer experiments (using labeled CH2H4folate) is marked with #.
