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Inhibition of ClC-0 by intracellular application of pentamer. Representative current families are shown from inside-out patches excised from Xenopus oocytes expressing ClC-0. Currents were measured initially (left), after steady-state inhibition in 50 μM pentamer (center), and after washing out unbound pentamer for 5 min (right). Currents were elicited by the voltage protocol shown below the trace on the right.
