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. Author manuscript; available in PMC: 2008 Oct 1.
Published in final edited form as: Eur J Neurosci. 2007 Oct 31;26(10):2719–2730. doi: 10.1111/j.1460-9568.2007.05928.x

Figure 7. Summary of Results.

Figure 7

Schematic presentation of the development of transient and persistent hippocampal events and oscillations based on previous research (black) and the present findings (red). SPWs and slow gamma oscillations (20–30 Hz) occurred at all ages examined. SPW-related fast gamma tails (60–100 Hz) and ripples (140–200 Hz) were first detected at P6 and P7, respectively. Interictal spikes (IISs) and associated pathological high-frequency oscillations (HFOs; 60–200 Hz) were first evoked by kainic acid infusion into the contralateral hippocampus at P7. The occurrence of SPW doublets increased and SPW width decreased transiently between P7 and P11. Potentiated SPWs were detected only in P8–11 subjects, although only in a subset of subjects at these ages. Finally, peak seizure susceptibility to kainic acid infusion, as indicated by the number of infusions required to evoke seizure activity, occurred at approximately P9.