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Structures of etoposide (VP16) and paclitaxel. The rings of each molecule are labeled as well as the carbon atoms where moieties have been introduced to generate prodrugs (4”-position in etoposide and 2’- and 7-positions in paclitaxel). In addition, some of the groups that have been used to generate these prodrugs are indicated at the right, where X represents the atom of attachment.
