Fig. 4.

TrkB is required for neurogenesis-dependent LTP. (A) LTP evoked in tamoxifen-induced TrkB^lox/lox-Cre and control mice. Experiments were conducted in hippocampal slices of TrkB^wt/wt-Cre mice in the absence (n = 8 slices, 4 animals) or presence (n = 6 slices, 2 animals) of ifenprodil (3 μM) and in slices of TrkB^lox/lox-Cre mice (n = 7 slices, 3 animals). Each point in the graph shows the average fEPSP slope elicited in response to a test stimulus before (−20–0 min) and after (0–60 min) tetanic stimulation of the MPP. Representative fEPSP traces recorded before (−5 min) and after (60 min) tetanus are shown on the top. (B) LTP evoked as in A in the presence of bicuculline (20 μM) (n = 4 slices, 4 animals).