Fig. 5.
Deletion of TrkB in newborn neurons affects exploratory activity in mice exposed to a novel environment. (A) Exploratory behavior of tamoxifen-induced TrkBlox/lox-Cre and control mice in the open-field test. Histograms show the number of entries and the percentage of time spent in the center, corner, or the entire periphery of the arena (n = 20) (*, P < 0.05). The total distance moved is shown in the right panel. (B) Exploratory behavior in the elevated plus maze test. Histograms show the proportion of entries and time spent in the open arms (n = 20) (*, P < 0.05). The total number of entries in the four arms is shown in the lower panel. (C) Digital tracking of mice exposed to the open-field (upper panels) and the elevated plus maze (lower panels) behavioral tests. Representative traces of mice pattern activity (red) resulting from video tracking are depicted. Each panel is representative of individual mice activity.