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. Author manuscript; available in PMC: 2008 Oct 7.
Published in final edited form as: J Biol Chem. 2005 Apr 29;280(26):24380–24385. doi: 10.1074/jbc.M502642200

Fig. 1. Effect of positive allosteric modulators on mGlu1, mGlu5 and mGlu5Ro quisqualate-induced activity.

Fig. 1

A–C. Effect of increasing doses of quisqualate on IP production by mGlu1, mGlu5 or mGlu5Ro receptor in the absence (open squares) or in presence of Ro01-6128 (black circles) or DFB (black triangles). Values are means ± S.E.M. of triplicate determinations from a representative experiment. D–F. Effect of Ro01-6128 and DFB on EC50 of quisqualate on mGlu1, mGlu5 or mGlu5Ro. EC50 values are normalized to that measured in the absence of modulator. Values are mean ± S.E.M. of n = 10, 8 and 7 experiments respectively.