Fig. 1. Effect of positive allosteric modulators on mGlu1, mGlu5 and mGlu5Ro quisqualate-induced activity.
A–C. Effect of increasing doses of quisqualate on IP production by mGlu1, mGlu5 or mGlu5Ro receptor in the absence (open squares) or in presence of Ro01-6128 (black circles) or DFB (black triangles). Values are means ± S.E.M. of triplicate determinations from a representative experiment. D–F. Effect of Ro01-6128 and DFB on EC50 of quisqualate on mGlu1, mGlu5 or mGlu5Ro. EC50 values are normalized to that measured in the absence of modulator. Values are mean ± S.E.M. of n = 10, 8 and 7 experiments respectively.