Fig. 4. Effect of positive allosteric modulators on heterodimers in which one subunit is unable to activate G-proteins.
A. Effect of increasing doses of quisqualate on IP production induced by mGlu5C1:mGlu1XC2 receptor activation in the absence of modulator (open squares), in presence of Ro01-6128 (black circles) or DFB (black triangles). Values are means ± S.E.M. of n = 5 experiments.