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. Author manuscript; available in PMC: 2008 Oct 7.
Published in final edited form as: J Biol Chem. 2004 May 4;279(28):29085–29091. doi: 10.1074/jbc.M400930200

Figure 6.

Figure 6

The ECD of GABAB1 or GABAB2 are not required for the effect of CGP7930. Effect of the CGP7930 (100 μM) in presence or no of GABA (1 mM) on chimeric receptor formed by the subunit combination GABAB1 + GABAB1/2 and GABAB2 + GABAB2/1, in which the ECD of GABAB2 and that of GABAB1 is missing respectively. 1 + 1/2 stands for the subunit combinations GABAB1 + GABAB1/2, and 1/2+2 stands for the subunit combination GABAB2/1 + GABAB2. CGP7930 was still able to stimulate the IP formation in cells expressing either combination, indicating that the ECD of GABAB1 or GABAB2 subunits are not necessary for the effect of CGP7930. The empty circle represents the ECD of GABAB1 and the black circle the ECD of GABAB2, and the empty square represents the HD of GABAB1 and the black square the HD of GABAB2. The presented data are means of three experiments performed in triplicate.