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Fluorescein-labeled U3 snoRNA is functional in rRNA processing. rRNA precursors (40, 32, and 20S) and products (28 and 18S) were labeled in vivo with [32P]UTP, and the isolated nuclear RNA was subjected to agarose gel electrophoresis. 18S rRNA is not formed after antisense oligonucleotide depletion of endogenous U3 snoRNA but is formed after subsequent injection of U3 snoRNA (0.3 and 1.0 μg/μl) with or without fluorescein (FL) label to rescue rRNA processing.
