Table 2.
The genes that significantly differed between survivors and deceased patients.
| A | |||||
| Gene Symbol | Accesion number | Gene Name | Expression deceased vs 10-year survivors | Gene Ontology, Function | van't Veer/Wang |
| ADA | NM_000022 | adenosine deaminase | Higher | adenosine deaminase activity, hydrolase activity | 1/1 |
| BCAT1 | NM_005504 | branched chain aminotransferase 1, cytosolic | Higher | branched-chain-amino-acid transaminase activity, catalytic activity, transferase activity | 1/1 |
| C9orf164 | NM_006378 | chromosome 9 open reading frame 164 | Higher | 0/0 | |
| CCDC99 | NM_017785 | coiled-coil domain containing 99 | Higher | 1/0 | |
| CCNB1IP1 | NM_182849 | cyclin B1 interacting protein 1 | Higher | ligase activity, metal ion binding | 1/1 |
| COMMD9 | NM_014186 | COMM domain containing 9 | Higher | 0/1 | |
| CPS1 | NM_001875 | carbamoyl-phosphate synthetase 1, mitochondrial | Higher | ATP binding, carbamoyl-phosphate synthase (ammonia) activity, ligase activity, nucleotide binding, protein binding | 1/2 |
| E2F2 | NM_004091 | E2F transcription factor 2 | Higher | protein binding, transcription factor activity | 1/1 |
| F2 | NM_000506 | coagulation factor II (thrombin) | Higher | calcium ion binding, receptor binding, thrombin activity, thrombin activity | 1/1 |
| GGH | NM_003878 | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) | Higher | exopeptidase activity, hydrolase activity | 1/1 |
| GIT2 | NM_014776 | G protein-coupled receptor kinase interactor 2 | Higher | GTPase activator activity, metal ion binding | 2/2 |
| GNG10 | NM_004125 | guanine nucleotide binding protein (G protein), gamma 10 | Higher | GTPase activity, heat shock protein binding, signal transducer activity | 1/0 |
| HPS5 | NM_007216 | Hermansky-Pudlak syndrome 5 | Higher | protein binding | 1/1 |
| KCNAB2 | NM_003636 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | Higher | ion channel activity, oxidoreductase activity, potassium channel regulator activity, potassium ion binding | 1/0 |
| MGC13057 | NM_032321 | hypothetical protein MGC13057 | Higher | 0/0 | |
| MRTO4 | NM_016183 | mRNA turnover 4 homolog (S. cerevisiae) | Higher | 0/1 | |
| MTERF | NM_006980 | mitochondrial transcription termination factor | Higher | DNA binding, double-stranded DNA binding, transcription termination factor activity | 1/1 |
| MYO1G | NM_033054 | myosin IG | Higher | ATP binding, motor activity | 0/0 |
| NPM3 | NM_006993 | nucleophosmin/nucleoplasmin, 3 | Higher | nucleic acid binding | 1/0 |
| PIR | NM_003662 | pirin (iron-binding nuclear protein) | Higher | metal ion binding, transcription cofactor activity | 1/1 |
| PLEKHM2 | XM_290944 | pleckstrin homology domain containing, family M (with RUN domain) member 2 | Higher | oxidoreductase activity | 0/0 |
| PRPS1L1 | NM_175886 | phosphoribosyl pyrophosphate synthetase 1-like 1 | Higher | kinase activity, lipoate-protein ligase B activity, magnesium ion binding, ribose phosphate diphosphokinase activity, transferase activity | 0/1 |
| RAB23 | NM_183227 | RAB23, member RAS oncogene family | Higher | GTP binding, nucleotide binding | 1/1 |
| RCN1 | NM_002901 | reticulocalbin 1, EF-hand calcium binding domain | Higher | calcium ion binding | 0/0 |
| RP5-1077B9.4 | NM_021933 | invasion inhibitory protein 45 | Higher | 1/0 | |
| SALL4 | NM_020436 | sal-like 4 (Drosophila) | Higher | DNA binding, metal ion binding, nucleic acid binding, protein binding | 0/0 |
| SERPINB9 | NM_004155 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | Higher | protein binding, serine-type endopeptidase inhibitor activity | 1/2 |
| SLC35B4 | NM_032826 | solute carrier family 35, member B4 | Higher | UDP-N-acetylglucosamine transporter activity, UDP-xylose transporter activity, nucleotide-sugar transporter activity, sugar porter activity | 0/0 |
| SPATA5 | NM_145207 | spermatogenesis associated 5 | Higher | ATP binding, nucleoside-triphosphatase activity, nucleotide binding | 0/0 |
| TM4SF5 | NM_003963 | transmembrane 4 L six family member 5 | Higher | 1/0 | |
| TRPV2 | NM_016113 | transient receptor potential cation channel, subfamily V, member 2 | Higher | calcium ion binding, ion channel activity | 2/0 |
| B | |||||
| Gene Symbol | Accesion number | Gene Name | Expression deceased vs 10-year survivors | Gene Ontology, Function | van't Veer/Wang |
| ARFIP1 | NM_001025595 | ADP-ribosylation factor interacting protein 1 (arfaptin 1) | Lower | identical protein binding | 1/0 |
| ARSD | NM_001669 | arylsulfatase D | Lower | arylsulfatase activity, calcium ion binding, hydrolase activity | 2/2 |
| C1orf43 | NM_015449 | chromosome 1 open reading frame 43 | Lower | 1/0 | |
| C4orf26 | NM_178497 | chromosome 4 open reading frame 26 | Lower | 0/0 | |
| CCDC24 | NM_152499 | coiled-coil domain containing 24 | Lower | 0/0 | |
| CUL7 | NM_014780 | cullin 7 | Lower | protein binding | 1/2 |
| EDEM3 | NM_025191 | ER degradation enhancer, mannosidase alpha-like 3 | Lower | calcium ion binding, mannosyl-oligosaccharide 1,2-alpha-mannosidase activity, peptidase activity | 0/0 |
| FAAH | NM_001441 | fatty acid amide hydrolase | Lower | amidase activity, hydrolase activity, receptor binding | 2/1 |
| FXYD3 | NM_005971 | FXYD domain containing ion transport regulator 3 | Lower | chloride ion binding, ion channel activity | 1/0 |
| GOLT1A | NM_198447 | golgi transport 1 homolog A (S. cerevisiae) | Lower | 1/0 | |
| NEIL1 | NM_024608 | nei endonuclease VIII-like 1 (E. coli) | Lower | DNA N-glycosylase activity, damaged DNA binding, hydrolase activity, acting on glycosyl bonds, lyase activity, oxidized purine base lesion DNA N-glycosylase activity, zinc ion binding | 1/0 |
| OR7E91P | NR_002185 | olfactory receptor, family 7, subfamily E, member 91 pseudogene | Lower | receptor activity | 0/0 |
| PHLDA3 | NM_012396 | pleckstrin homology-like domain, family A, member 3 | Lower | 1/0 | |
| PLEKHA6 | NM_014935 | pleckstrin homology domain containing, family A member 6 | Lower | 1/1 | |
| RORC | NM_005060 | RAR-related orphan receptor C | Lower | metal ion binding, sequence-specific DNA binding, steroid hormone receptor activity, transcription factor activity | 1/1 |
| TAF5L | NM_014409 | TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65 kDa | Lower | transcription factor activity | 1/1 |
| TMEM63A | NM_014698 | transmembrane protein 63A | Lower | 1/4 | |
| ZNF497 | NM_198458 | zinc finger protein 497 | Lower | metal ion binding, nucleic acid binding | 0/0 |
| ZNF691 | NM_015911 | zinc finger protein 691 | Lower | metal ion binding, nucleic acid binding | 0/0 |
| ZNF692 | NM_017865 | zinc finger protein 692 | Lower | metal ion binding, nucleic acid binding | 1/0 |
A, Biological function of the genes with significantly higher expression in the tumours from deceased patients compared to the tumours from 10-year survivors.
B, Biological function of the genes with significantly lower expression in the tumours from deceased patients compared to the tumours from 10-year survivors.
Gene Symbol, Gene Name and Gene Ontology information was captured from Entrez Gene. The last column shows the number of replicates in the suydies by van't Veer et al. and Wang et al., respectively.