Table 3. McDonald-Kreitman analyses of Pvama1 and Pfama1.

	Region	Polymorphic changes within species	Polymorphic changes within species	Fixed differences between species	Fixed differences between species	Neutrality index1	Fisher's exact test2
		Synonymous	Nonsynonymous	Synonymous	Nonsynonymous
P. vivax vs	Whole	6	21	119	69	6.04	0.000095**
P. cynomolgi	DI	3	11	35	19	6.75	0.0057*
	DII	2	2	21	11	1.91	0.61
	DIII	0	2	12	10	-	0.48
P. vivax vs	Whole	9	22	130	82	3.88	0.00086**
P. knowlesi	DI	4	12	37	21	5.29	0.0095*
	DII	2	2	20	21	1.67	1.00
	DIII	1	2	15	3	10.00	0.13
P. falciparum vs	Whole	0	29	19	53	-	0.0013*
P. reickenowi	DI	0	14	4	10	-	0.098
	DII	0	5	3	4	-	0.20
	DIII	0	3	1	5	-	1.00

¹ = Neutrality index indicates the extent to which the levels of amino acid polymorphism depart from the expected in the neutral model.

² = Fisher's exact test.

*0.001<P<0.01; ** P<0.001.