Table III.
Most frequently occurring HCPIN domains
Frq, frequency; seq id, sequence identity; PH, pleckstrin homology; zf, zinc finger; Ank, ankyrin.
| Pfam domain name | Frq | Modeling coveragea (E-value <10−6 and >80% seq id) | Molecular function |
|---|---|---|---|
| Collagen | 265 | 0.01 | Extracellular structural proteins |
| Pkinase | 184 | 0.31 | Protein kinase |
| zf-C2H2 | 176 | 0.17 | Nucleic acid binding |
| WD40 | 173 | 0.23 | Multiprotein complex assemblies |
| LRR_1 | 148 | 0.22 | Leucine-rich repeat, protein-protein interaction |
| Ank | 145 | 0.40 | Protein-protein interaction motif |
| fn3 | 134 | 0.18 | Cell surface binding, signaling |
| EGF | 122 | 0.12 | EGF-like domain |
| SH3_1 | 104 | 0.46 | Signal transduction related to cytoskeletal organization |
| Ldl_recept_b | 101 | 0.05 | Low density lipoprotein receptor repeat class B |
| TPR_1 | 99 | 0.32 | Protein-protein interaction |
| EGF_CA | 94 | 0.10 | Calcium-binding EGF domain |
| IQ | 81 | 0.00 | Calmodulin-binding motif |
| efhand | 79 | 0.47 | Calcium-binding domain |
| ig | 77 | 0.27 | Immunoglobulin domain |
| Ldl_recept_a | 77 | 0.13 | Low density lipoprotein receptor repeat class A |
| SH2 | 74 | 0.58 | Intracellular signaling |
| Pkinase_Tyr | 73 | 0.41 | Protein-tyrosine kinase |
| Filamin | 72 | 0.03 | Actin cross-linking protein |
| PH | 65 | 0.26 | Cytoskeleton, intracellular signaling |
| Spectrin | 64 | 0.08 | Cytoskeletal structure |
a
The percentage of domain members that can be modeled at BLAST E-value <10−6 and >80% sequence identity.