Fig. 8.

Protein fluctuations over time by cell signaling pathway. Leiomyoma tissue replicates incubated at room temperature and analyzed by RPPA reveal pathway- and protein-specific increases and decreases over time (n = 3 for 44 and 60 min; n = 4 for 119, 146, and 191 min; n = 5 for 949 min; ±S.D. as a percentage of time 0 sample). Cell signaling pathways represented are: apoptosis (A), adhesion (B), hypoxia (C), glucose/insulin signaling (D), proliferation/survival (E), cell cycle (F), stress/inflammation (G), and transcription factors (H). FAK, focal adhesion kinase; AcCoA, acetyl-CoA carboxylase.