Table 1.
Demographics of Animal Cohorts
| Animal | Sex | Agea | Survivalb | Inoculumc | Reason for Euthanasia & Other Findings | CNS Pathology |
|---|---|---|---|---|---|---|
| C1 | F | 3.9 | n.a. | n.a. | Termination of study | Healthy control |
| C2 | M | 3.7 | n.a. | n.a. | Termination of study | Healthy control |
| C3 | F | 2.5 | n.a. | n.a. | Termination of study | Healthy control |
| C4 | M | 2.3 | n.a. | n.a. | Termination of study | Healthy control |
| C5 | M | 6.9 | n.a. | n.a. | Termination of study | Healthy control |
| C6 | F | 7.3 | n.a. | n.a. | Termination of study | Healthy control |
| M1 | F | 8.5 | 70 | SIVmac251d | Wasting due to AIDS | Severe encephalitis |
| M2 | F | 9.6 | 63 | SIVmac251d | Wasting due to AIDS | Severe encephalitis |
| M3 | F | 9.6 | 56 | SIVmac251d | Wasting due to AIDS; diarrhea | Severe encephalitis |
| M4 | M | 3.0 | 157 | SIVmac251 | Facial edema; wasting due to AIDS; diarrhea | Severe encephalitis |
| M5 | M | 3.8 | 187 | SIVmac239 | Wasting due to AIDS; diarrhea; pneumonia | Severe encephalitis |
| M6 | M | 10.3 | 103 | SIVmac239 | Lethargy, poor health; CMV pneumonia | Severe encephalitis |
| M7 | M | 6.3 | 535 | SIVmac239 | Weight loss; neurologic signs | Atypical severe encephalitis |
| M8 | M | 3.9 | 124 | SIVmac251 | Wasting due to AIDS; CMV; pneumonia | Moderate encephalitis |
| M9 | F | 2.9 | 100 | SIVmac239 | Wasting; diarrhea | Moderate encephalitis |
| M10 | M | 4.5 | 67 | SIVmac251 | Wasting; anorexia; vomiting; CMV | Moderate encephalitis |
| M11 | M | 3.1 | 523 | SIVmac251 | Wasting due to AIDS; diarrhea | Moderate encephalitis |
| M12 | F | 2.6 | 176 | SIVmac251 | Enteritis; wasting due to AIDS; diarrhea | Mild encephalitis |
| M13 | M | 4.6 | 160 | SIVmac251 | Wasting due to AIDS; paresis; CMV | Mild encephalitis |
| M14 | M | 5.6 | 407 | SIVmac251 | Wasting due to AIDS; diarrhea; visual deficits | Mild encephalitis |
| M15 | M | 2.7 | 467 | SIVmac239 | Dehydration; paresis; enlarged liver | Mild encephalitis |
| M16 | M | 3.2 | 769 | SIVmac239 | Multicentric lymphoma | Mild encephalitis |
| M17 | M | 3.7 | 348 | SIVmac251 | Wasting due to AIDS; diarrhea; enteritis | Mild encephalitis |
| M18 | M | 3.4 | 293 | SIVmac251 | Severe oral disease, myocarditis | No encephalitis |
| M19 | M | 4.8 | 392 | SIVmac251 | Wasting due to AIDS; lymphoproliferative disease | No encephalitis |
| M20 | F | 4.1 | 103 | SIVmac251 | Pneumonia; oophoritis | No encephalitis |
| M21 | M | 1.7 | 173 | SIVmac239 | Wasting due to AIDS; microsporidia in liver | No encephalitis |
| M22 | M | 4.8 | 77 | SIVmac251 | Severe diarrhea; dehydration; anorexia | No encephalitis |
| M23 | M | 2.1 | 153 | SIVmac251 | Wasting due to AIDS; facial edema; anorexia | No encephalitis |
a
Age reported in years. The mean age was 3.0 years for juveniles and 6.5 years for adults. See Materials and Methods for explanation of juvenile and adult groupings.
b
Survival postinoculation reported in days.
c
Both SIVmac251 and 239 are known to be neurotropic and cause SIVE. N.A. indicates uninfected animals used as healthy controls.
d
Designates animals that were also CD8-depleted coincident with SIV inoculation.