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Model for Antisense Oligonucleotide Disruption of miRNA Silencing. Single-stranded, mature miRNAs bound to an Argonaute protein can cleave perfectly complementary mRNA targets. Imperfectly paired mRNAs are translationally repressed or degraded. ASOs bind miRNAs in RISC, thereby preventing miRNA from binding its target mRNA. In some cases, ASOs may secondarily promote miRNA degradation by an unknown mechanism.
