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. Author manuscript; available in PMC: 2009 Sep 11.
Published in final edited form as: J Med Chem. 2008 Aug 8;51(17):5441–5448. doi: 10.1021/jm800555h

Table 1.

GAR and AICAR Tfase Inhibition (Ki, μM)

Compound rhGAR Tfase rhAICAR Tfase
10R-3 0.21 > 100
10S-3 0.18 > 100
10R-7 1.1 > 100
10S-7 1.4 > 100
10R-8 0.85 > 100
10S-8
9
DDACTHF
2 		1.2
1.1
1.7
0.03		 > 100
20
20
> 100
Lometrexol 0.06a > 100
a

Ref 18