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In vitro Cytotoxic Activity
| Compound | CCRF-CEM (IC50, μM) | ||
|---|---|---|---|
| (-) T, (-) H | (+) T, (-) H | (-) T, (+) H | |
| 10R-3 | 0.08 | 0.08 | >10 |
| 10S-3 | 0.05 | 0.07 | >10 |
| 10R-7 | 2.4 | 5.7 | >10 |
| 10S-7 | 0.5 | 0.6 | >10 |
| 10R-8 | 0.5 | 0.7 | >10 |
| 10S-8 | 0.7 | 0.9 | >10 |
| 9 | >100 | >100 | >10 |
| DDACTHF 2 |
2.7 0.016 |
3.6 0.017 |
>10 >10 |
| Lometrexol | 0.2 | 0.2 | >10 |
