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. Author manuscript; available in PMC: 2009 Sep 11.
Published in final edited form as: J Med Chem. 2008 Aug 8;51(17):5441–5448. doi: 10.1021/jm800555h

Table 3.

In vitro Cytotoxic Activity in Mutant Cell Lines

Compound IC50, μM [(-)T, (-)H]
CCRF-CEM CCRF-CEM/FPGS- CCRF-CEM/MTX
10R-3 0.09 5.5 0.07
10S-3 0.06 5.0 0.06
10R-7 5.50 >10 4.4
10S-7 0.60 >10 0.6
10R-8 0.60 6.0 0.6
10S-8 0.80 >10 0.9
9 >100 nd nd
DDACTHF
2
2.7
0.06
>10
>10
>100
nd
Lometrexol 0.20 >10 nd (>100)a
a

Ref 18