Table 1.

Generation of OXPHOS-competent clones after fusion of cytoplasts from different apes with human cell lines harboring no or homoplasmic mutated mtDNA

Human recipient	mtDNA donor
	Human	Common chimp	Pigmy chimp	Gorilla
143B/206 (ρ°)	449	385	392	408
Δ16.10.40	141	0	2a	0
W72	226	ND	ND	3b

Data are from representative fusion experiments using similar amounts of mtDNA donors (∼3 × 10⁵ enucleated fibroblasts) and recipient donors (1.5 × 10⁶ osteosarcoma-derived cell). ND, not done. 

^aTwo clones containing low levels of pigmy chimp mtDNA were isolated and grown for 30 d, at which point they became unable to sustain growth in uridine-lacking selective medium and died. 

^bA fusion between W72 and gorilla cytoplasts yielded nine clones after galactose selection, but only three contained gorilla mtDNA. One of them contained <10% gorilla mtDNA, whereas the other two were homoplasmic.