Comparison of the response to HT between the WHI RCT and our Population Studies. The response of women with an intact uterus treated with combined HT is shown in the left panel, and those with a prior hysterectomy treated with estrogen only is shown on the right. The data for each outcome is grouped with the response of older women in the upper and younger women in the lower portion.
Abbreviations: CHD – coronary heart disease in WHI RCT or myocardial infarction only in GPRD studies, CVA – cerebrovascular accident.
The legend defines the age of the study group. Cox adjusted HR’s are shown for all data except those labeled PERR, which were analyzed with this adjustment. “Missing data” in the death analysis refers to a subset of the cohort that was not missing any data on the potential confounders – blood pressure, BMI, and smoking.