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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Fertil Steril. 2008 Aug;90(2):258–264. doi: 10.1016/j.fertnstert.2008.05.031

TABLE 2.

WHI RCT AND GPRD STUDIES in WOMEN WITH A PRIOR HYSTERECTOMY TREATED WITH ESTROGEN ONLY

WHI RCTa
(50 – 79 yrs)		 WHI RCTb
(50 – 70 yrs)		 WHI RCTb
(50 – 59 yrs)
Treated Placebo HR (95% CI) Treated Placebo HR (95% CI) Treated Placebo HR (95% CI)
Estrogen only Estrogen only Estrogen only
(n) 5310 5429 4024 4128 1637 1673
CHD 177 199 0.91 [0.75–1.12] 117 140 0.86 [0.67–1.11] 21 34 0.63 [0.36–1.09]
CVA 158 118 1.39 [1.10–1.77] 102 75 1.40 [1.03–1.91] 18 21 0.89 [0.47–1.69]
DEATH 291 289 1.04 [0.88–1.22] 163 179 0.94 [0.75–1.16] 34 48 0.71 [0.46–1.11]
GPRD STUDYc
(55 – 79 yrs)		 GPRD STUDYc
(50 – 55 yrs)
Exp UnExp Adj HR (95% CI) Exp UnExp Adj HR (95% CI)
Estrogen only Estrogen only
(n) 6890 11,572 6842 9624
MI 59 238 0.50 [0.38–0.67]d 39 66 0.85 [0.57–1.37]f
CVA 93 191 0.95 [0.74–1.23]e 52 72 1.10 [0.76–1.58]g
DEATH 182 497 0.68 [0.57–0.81] 65 169 0.53 [0.40–0.71]
a

Reference (7), 24% of women were older than 70 years versus 5.2% of women in the GPRD study

b

Reference (8)

c

Reference (12)

d

Adjusted HR using PERR = 1.28 (0.69–2.56)

e

Adjusted HR using PERR = 3.06 (1.39 – 10.31)

f

Adjusted HR using PERR = .92 (.35–2.79)

g

Adjusted HR using PERR = 2.32 (.98–7.94)