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. 2008 Oct 14;3(10):e3399. doi: 10.1371/journal.pone.0003399

Figure 10. Timecourse of age-related changes.

Figure 10

(A) Averaged RF-size for each individual animal plotted as a function of age. RFs on the hindpaw (light blue squares), RFs on the forepaw (dark blue squares). Until an age of approximately 24 months we found no age related alterations of RF-size of fore- and hindpaw cortical neurons. Beyond that age RFs on the hindpaw increasingly enlarged with advancing age, with the largest RFs found in the animals with the highest age. For the forepaw no comparable increase was observed. (B) Averaged peak-latencies for each individual animal plotted as a function of age. Light blue squares Latencies of neurons recorded in the representation of the hindpaw (light blue squares), latencies of neurons from the forepaw representation (dark blue squares). Similar to RF-size, we found no age related lengthening of peak latencies until an age of about 24 months. From then on latencies of neurons from both the fore- and the hindpaw representation were increasingly lengthened with advancing age.