Table 1.
WT | CS-KO | |
Number of animals | 20 | 18 |
Physical characteristics | ||
- Weight (g) | 26.2 (± 0.33) | 27.1 (± 0.40) |
- Body temperature (°C) | 36.9 (± 0.20) | 37.1 (± 0.18) |
- Whiskers (% with) | 100 | 89 |
- Fur (% with normal fur) | 100 | 100 |
Sensory and motor reflexes | ||
- Ear twitch (% with normal response) | 100 | 83 |
- Key jangling (% with normal response) | 95 | 89 |
- Whisker twitch | 100 | 94 |
- Righting reflex | 100 | 100 |
Pain test | ||
- Hot plate (latency; seconds) | 6.75 (± 0.349) | 6.05 (± 0.364) |
Motor tests | ||
- Wire hang (% stayed up to 60 s) | 95 | 94 |
- Grip strength (N) | 0.893 (± 0.03) | 0.825 (± 0.03) |
No significant differences between genotypes were detected in physical characteristics (weight, body temperature, whiskers and fur), sensory and motor reflex (ear twitch response, key-jangling response and righting reflex), hot plate test (latency to the first paw response), and muscular abilities (number of animals that stayed up to 60 sec in wire hang test and grip strength).