Table 2. Accuracy for the diagnosis of active tuberculosis.

Sensitivity*		RD1 selected peptides test	TST	QuantiFERON-TB GOLD In-Tube	T-SPOT.TB
		Positive over total (%) [CI]
According to diagnostic criteria	Confirmed TB	127/173 (73.4)	114/136 (83.8)	99/121 (81.8)	62/69 (89.9)
		[66.2–79.8]	[76.5–89.6]	[73.8–88.2]	[80.2–95.8]
	Clinical TB	31/43 (72.1)	37/41 (90.2)	22/34 (64.7)	13/19 (68.4)
		[56.3–84.7]	[76.9–97.3]	[46.5–80.3]	[43.4–87.4]
According to TB localization	Pulmonary	109/146 (74.7)	100/115 (87.0)	88/107 (82.2)	49/56 (87.5)
		[66.8–81.5]	[79.4–92.5]	[73.7–89.0]	[75.9–94.8]
	Extra-pulmonary	40/56 (71.4)	41/47 (89.4)	26/39 (66.7)	17/23 (73.9)
		[57.8–82.7]	[76.9–96.5]	[49.8–80.9]	[51.6–89.8]
	Pulmonary and extra-pulmonary	9/14 (64.3)	9/15 (60.0)	7/9 (77.8)	9/9 (100)
		[35.1–87.2]	[32.3–83.7]	[40.0–97.2]	[71.7–100.0]
Total		158/216 (73.1)	151/177 (85.3)	121/155 (78.1)	75/88 (85.2)
		[66.7–78.9]	[79.2–90.2]	[70.7–84.3]	[76.1–91.9]
Specificity **
		139/197 (70.6)	72/150 (48.0)	60/97 (61.9)	43/97 (44.3)
		[63.7–76.8]	[39.8–56.3]	[51.4–71.5]	[34.2–54.8]
Positive likelihood ratio ***
		2.48	1.64	2.05	1.53
		[1.97–3.1]	[1.39–1.94]	[1.57–2.67]	[1.26–1.87]
Negative likelihood ratio ***
		0.38	0.31	0.35	0.33
		[0.30–0.48]	[0.21–0.45]	[0.25–0.50]	[0.19–0.58]

^*evaluated on the total number of positive results over the total number of patients with active tuberculosis disease.

^**evaluated on the total number of negative results over the total number of patients without active tuberculosis disease.

^***evaluated on the total number of tuberculosis cases (confirmed and clinical tuberculosis).

Abbreviations:

TB: tuberculosis; RD: region of difference; TST: tuberculin skin test; CI: confidence interval.