Table 2.
Interaction of smoking and BAL CD8 and CD3 chemokine receptor expression.
| Current smoking effects Current versus ex-smokers: Data from COPD patients and smokers are combined | ||||||
|---|---|---|---|---|---|---|
| BAL CD8 cells | BAL CD3 cells | |||||
| Current n = 14 | Ex n = 12 | Non-paired t-test P value | Current n = 14 | Ex n = 12 | Non-paired t-test P value | |
| CCR3 | 19·9 (5·8) | 22·3 (6·9) | 0·39 | 11·7 (4) | 9·5 (2·3) | 0·32 |
| CCR4 | 33·4 (6·7) | 20·1 (4·4) | 0·06 | 20·6 (4·2) | 10·6 (3·1) | 0·07 |
| CCR5 | 55·4 (7·5) | 36·3 (7·9) | 0·04 | 33·3 (4·1) | 21·3 (5·3) | 0·04 |
| CXCR3 | 45·4 (6·7) | 37·2 (8·4) | 0·22 | 29·3 (4·8) | 21·9 (6) | 0·17 |
| Analysis of ex- and non-smokers: COPD ex-smokers versus ex-smokers (Hex) versus HNS | ||||||||
|---|---|---|---|---|---|---|---|---|
| BAL CD8 cells | BAL CD3 cells | |||||||
| COPD ex n = 6 | Hex n = 6 | HNS n = 8 | Three-way anovaP value | COPD ex n = 6 | Hex n = 6 | HNS n = 8 | Three-way anovaP value | |
| CCR3 | 30·1 (12·3) | 14·5 (5·6) | 3·4 (1·4) | 0·03 | 12·2 (3·8) | 6·9 (2·3) | 1·1 (0·3) | 0·019 |
| CCR4 | 27·9 (6·9) | 12·4 (4) | 21·5 (5·6) | 0·23 | 14·4 (5·5) | 6·8 (2·8) | 7 (1·5) | 0·26 |
| CCR5 | 41·8 (12·9) | 30·9 (9·8) | 21·6 (6·4) | 0·32 | 22·8 (7·8) | 19·9 (8) | 6·5 (2·8) | 0·18 |
| CXCR3 | 31·7 (9·1) | 42·7 (14·7) | 36 (10·5) | 0·82 | 17·3 (5·9) | 26·4 (10·7) | 9·5 (2·7) | 0·24 |
Mean per cent cell chemokine receptor expression (standard error of the mean). Hex, ex-smoker with normal lung function.