Table 1.
Comparison of hepatocellular integrity and cholestasis markers between, study (HIV and HBV or HCV co-infected patients) and control (HIV mono-infected patients) at the baseline and after 24 months of follow-up
| Marker (Reference range) | Study point | HIV mono-infected (n = 18) | HBV or HCV co-infected (n = 9) | P value |
|---|---|---|---|---|
| AST (<31 U l–1) | Baseline | 27 ± 3 | 35 ± 4 | NS |
| Month 24 | 24 ± 2 | 36 ± 7 | NS | |
| P value | NS | NS | ||
| ALT (<31 U l–1) | Baseline | 49 ± 5 | 59 ± 9 | NS |
| Month 24 | 34 ± 3 | 58 ± 9 | 0.0297 | |
| P value | 0.0222 | NS | ||
| AST : ALT (<1) | Baseline | 0.56 ± 0.04 | 0.71 ± 0.16 | NS |
| Month 24 | 0.85 ± 0.12 | 0.68 ± 0.04 | NS | |
| P value | 0.0267 | NS | ||
| AP (35–104 U l–1) | Baseline | 89 ± 5 | 94 ± 9 | NS |
| Month 24 | 80 ± 5 | 84 ± 9 | NS | |
| P value | NS | NS | ||
| GGT (<36 U l–1) | Baseline | 67 ± 13 | 114 ± 31 | NS |
| Month 24 | 55 ± 10 | 140 ± 44 | NS | |
| P value | NS | NS | ||
| Total bilirubin (<1.00 mg l–1) | Baseline | 0.31 ± 0.04 | 0.37 ± 0.06 | NS |
| Month 24 | 0.52 ± 0.07 | 0.57 ± 0.13 | NS | |
| P value | 0.0118 | NS | ||
| Direct bilirubin (<0.30 mg l–1) | Baseline | 0.11 ± 0.01 | 0.11 ± 0.03 | NS |
| Month 24 | 0.24 ± 0.03 | 0.21 ± 0.02 | NS | |
| P value | 0.0002 | 0.0352 |
Data are expressed in mean ± SEM. ns, non significant (p > 0.05). ALT, alanine aminotransferase; AP, alkaline phosphatase; AST, aspartate aminotransferase. GGT: γ-glutamyltranspeptidase.