Table 1.
Demographic characteristics and biochemical parameters of children administered a single dose (0.3 mg kg-1) of midazolam (MDZ) intravenously (i.v.), intramuscularly (i.m.) or via buccal cavity
| Parameter | IV midazolam | IM midazolam | Buccal midazolam | P value |
|---|---|---|---|---|
| Demography | ||||
| Number of children | 13 | 12 | 8 | – |
| Gender (M : F) | 5 : 8 | 5 : 7 | 4 : 4 | – |
| Age (months)* | 27 (7–39) | 25 (9–96) | 26 (7–64) | 0.852 |
| Weight (kg) | 10.4 (8.7, 12.1) | 11.3 (8.8, 13.9) | 10.1 (7.9, 12.4) | 0.872 |
| Weight-for-age Z (WAZ) score | −1.6 (−3.6, 1.8) | −1.3 (−4.2, 0.0) | −1.6 (−4.0, −0.1) | |
| Number of malnourished children (WAZ ≤3) | 3 (23%) | 1 (8%) | 2 (25%) | – |
| Laboratory parameters | ||||
| Haemoglobin (g dl−1) | 7.3 (6.1, 8.5) | 7.9 (6.2, 9.7) | 7.6 (4.5, 10.7) | 0.611 |
| WBC (×106); µl−1* | 11.8 (8.2, 15.5) | 15.6 (8.7, 22.4) | 19.7 (6.2, 33.2) | 0.321 |
| Parasite count (µl−1); geometric mean | 36 163 | 69 255 | 26 242 | – |
| Sodium (mmol l−1) | 138 (136, 140) | 134 (130, 137) | 133 (131, 135) | 0.059 |
| Potassium (mmol l−1) | 4.4 (4.0, 4.7) | 4.2 (3.8, 4.6) | 3.9 (3.3, 4.6) | 0.295 |
| Creatinine (µmol l−1) | 55 (31, 79) | 53 (40, 66) | 41 (32, 50) | 0.198 |
| Blood glucose (mmol l−1) | 8.1 (4.4, 11.7) | 6.7 (4.2, 9.2) | 4.3 (−0.65, 8.3) | 0.294 |
| Hypoglycaemia (blood glucose <2.2 mmol l−1); (n) | 1 | 1 | 4 | – |
| pH | 7.16 (6.98, 7.33) | 7.25 (7.18, 7.32) | 7.12 (6.96, 7.28) | 0.854 |
| Base excess | −10.5 (−14.9, −5.9) | −8.3 (−11.5, −5.2) | −12.3 (−15.2, −9.4) | 0.852 |
Values are expressed as mean (95% confidence interval; CI) or
*
median (range), except parasite count, which is expressed as geometric mean.