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Parameter estimates from a healthy study population used as prior information for the sufficient design in patients with HIV infection
| Parameter | Mean |
|---|---|
| Pharmacokinetic parameters | |
| CL (l h−1) | 1.18 |
| V (l) | 55.7 |
| Ka (h−1) | 3.38 |
| Alag (h) | 0.23 |
| Between-subject variability | CV% |
| BSVCL | 22.2 |
| BSVV | 17.4 |
| BSVKa | 177.8 |
| Residual variability | |
| Proportional error (CV%) | 14.7 |
| Additive error (mg l−1) | 0.08 |
| Limit of quantification (mg l−1) | 0.2 |
