Figure 2.

Myelin basic protein (MBP)-elicited cytokine production by patient and control cells. Mononuclear cells from 22 untreated patients with multiple sclerosis [MS; 20 with relapsing–remitting MS (RRMS); two with clinically isolated syndrome (CIS)] and 22 healthy controls (Ctrl) were grown in the presence of human MBP (30 μg/ml) or no antigen. The resulting net production of tumour necrosis factor-α (TNF-α; a) and interleukin-10 (IL-10; b) at day 1, and interferon-γ at day 7 (IFN-γ; c), after subtraction of the background production in the absence of stimulating antigen is shown. The backround production was similar in patients and controls, < 34 pg/ml for TNF-α, < 60 pg/ml for IL-10 and < 3 pg/ml for IFN-γ. Horizontal bars represent median values.