Figure 5.

Correlation between myelin basic protein (MBP)-induced T-cell proliferation, interleukin-17 (IL-17) production and disease activity. Mononuclear cell (MNC) cultures from 18 patients with multiple sclerosis (MS) were incubated with human MBP for 10 days. The proportion of divided CD4⁺ T cells at day 10 (a), and the content of IL-17 (b), IL-5 (c), and interferon-γ (IFN-γ) (d) in the culture supernatants at day 7 correlated with the number of brain plaques, as assessed by magnetic resonance imaging. Closed circles represent the high-responders who were scanned. *Represents multiple values of 0, 0 [nine in (a–c), six in (d)].