TABLE 3.
Age-adjusted odds ratios for quartiles of other anthropometric characteristics by tumor subtype
| Controls n (%) | Luminal cases | HER2-overexpressing cases | Triple-negative cases | ||||
|---|---|---|---|---|---|---|---|
| n (%) | OR* (95% CI) | n (%) | OR* (95% CI) | n (%) | OR* (95% CI) | ||
| Height, cm | |||||||
| Quartiles: < 157 | 362 (25) | 222 (22) | 1.0 (ref) | 11 (28) | 1.0 (ref) | 13 (17) | 1.0 (ref) |
| 157–160 | 362 (25) | 227 (23) | 1.0 (0.8–1.3) | 10 (26) | 0.9 (0.4–2.1) | 15 (19) | 1.1 (0.5–2.3) |
| 161–165 | 395 (27) | 301 (30) | 1.2 (1.0–1.5) | 11 (28) | 0.9 (0.4–2.0) | 26 (34) | 1.6 (0.8–3.3) |
| > 165 | 328 (23) | 258 (26) | 1.2 (1.0–1.5) | 7 (18) | 0.6 (0.2–1.6) | 23 (30) | 1.5 (0.7–3.1) |
| Trend test | p = 0.05 | p = 0.34 | p = 0.13 | ||||
| Continuous (per cm): | 1.01 (1.00–1.02) | 1.00 (0.95–1.05) | 1.02 (0.98–1.05) | ||||
| Lifetime maximum BMI, kg/m2 | |||||||
| Quartiles: < 25.0 | 362 (25) | 235 (23) | 1.0 (ref) | 12 (31) | 1.0 (ref) | 15 (19) | 1.0 (ref) |
| 25.0–27.9 | 361 (25) | 241 (24) | 1.0 (0.8–1.3) | 7 (18) | 0.6 (0.2–1.5) | 17 (22) | 1.1 (0.5–2.3) |
| 28.0–32.3 | 363 (25) | 261 (26) | 1.1 (0.9–1.4) | 7 (18) | 0.6 (0.2–1.5) | 21 (27) | 1.4 (0.7–2.8) |
| > 32.3 | 361 (25) | 271 (27) | 1.1 (0.9–1.4) | 13 (33) | 1.0 (0.5–2.3) | 24 (31) | 1.5 (0.7–2.8) |
| Trend test | p = 0.22 | p = 0.91 | p = 0.21 | ||||
| Continuous (per kg/m2): | 1.01 (1.00–1.02) | 1.00 (0.95–1.05) | 1.03 (1.00–1.06) | ||||
| Lifetime maximum weight, lbs | |||||||
| Quartiles: ≤ 140 | 369 (26) | 224 (22) | 1.0 (ref) | 13 (33) | 1.0 (ref) | 11 (14) | 1.0 (ref) |
| 141–160 | 380 (26) | 277 (27) | 1.2 (0.9–1.5) | 7 (18) | 0.5 (0.2–1.3) | 18 (23) | 1.5 (0.7–3.2) |
| 161–185 | 349 (24) | 245 (24) | 1.1 (0.9–1.4) | 9 (23) | 0.7 (0.3–1.7) | 24 (31) | 2.2 (1.0–4.5)† |
| >185 | 349 (24) | 262 (26) | 1.2 (0.9–1.5) | 10 (26) | 0.7 (0.3–1.7) | 24 (31) | 1.9 (0.9–4.0) |
| Trend test | p = 0.23 | p = 0.60 | p = 0.05 | ||||
| Continuous (per lb): | 1.00 (1.00–1.01)† | 1.00 (0.99–1.01) | 1.01 (1.00–1.01)† | ||||
| Weight at age 30, lbs | |||||||
| Quartiles: <120 | 389 (27) | 263 (26) | 1.0 (ref) | 15 (38) | 1.0 (ref) | 20 (26) | 1.0 (ref) |
| 120–128 | 367 (25) | 215 (21) | 0.9 (0.7–1.1) | 8 (21) | 0.6 (0.2–1.4) | 12 (16) | 0.7 (0.3–1.5) |
| 129–140 | 323 (22) | 270 (27) | 1.2 (1.0–1.5) | 6 (15) | 0.5 (0.2–1.2) | 16 (21) | 0.9 (0.5–1.8) |
| > 140 | 368 (25) | 260 (26) | 1.1 (0.8–1.3) | 10 (26) | 0.7 (0.3–1.6) | 29 (38) | 1.5 (0.8–2.7) |
| Trend test | p = 0.22 | p = 0.31 | p = 0.11 | ||||
| Continuous (per lb): | 1.00 (0.99–1.01) | 0.99 (0.96–1.03) | 1.01 (1.00–1.03) | ||||
| BMI at age 30, kg/m2 | |||||||
| Quartiles: < 20.8 | 362 (25) | 258 (26) | 1.0 (ref) | 11 (28) | 1.0 (ref) | 21 (27) | 1.0 (ref) |
| 20.8–22.3 | 361 (25) | 233 (23) | 0.9 (0.7–1.2) | 9 (23) | 0.8 (0.3–2.0) | 18 (23) | 0.9 (0.5–1.7) |
| 22.4–24.3 | 362 (25) | 279 (28) | 1.1 (0.9–1.4) | 6 (15) | 0.6 (0.2–1.6) | 11 (14) | 0.6 (0.3–1.2) |
| > 24.3 | 362 (25) | 238 (24) | 0.9 (0.8–1.2) | 13 (33) | 1.2 (0.5–2.8) | 27 (35) | 1.4 (0.8–2.5) |
| Trend test | p = 0.91 | p = 0.74 | p = 0.41 | ||||
| Continuous (per kg/m2): | 1.00 (0.97–1.02) | 0.99 (0.90–1.08) | 1.03 (0.98–1.09) | ||||
| Weight change (age 30 vs. reference, lbs) | |||||||
| Overall | |||||||
| Weight loss | 201 (14) | 71 (7) | 0.5 (0.3–0.6)† | 3 (8) | 0.5 (0.1–1.8) | 9 (12) | 1.1 (0.5–2.4) |
| Weight gain (tertiles): < 18 | 407 (28) | 320 (32) | 1.0 (ref) | 13 (33) | 1.0 (ref) | 20 (26) | 1.0 (ref) |
| 18–37 | 416 (29) | 289 (29) | 0.9 (0.7–1.1) | 10 (26) | 0.7 (0.3–1.7) | 25 (32) | 1.1 (0.6–2.0) |
| > 37 | 423 (29) | 328 (33) | 1.0 (0.8–1.2) | 13 (33) | 0.9 (0.4–2.0) | 23 (30) | 1.0 (0.5–1.8) |
| Continuous (per lb): | 1.00 (1.00–1.01)† | 1.01 (0.99–1.02) | 1.00 (0.99–1.01) | ||||
*
Odds ratio (OR) adjusted for age and reference year.
†
p<0.05.