Table 3.
The effect of brevenal of human lymphocytes exposed to brevetoxins
| Treatment | N | Tail moment Mean±SE |
|---|---|---|
| Negative control | 30 | 29.2+0.9 |
| H2O2 (2.75%) | 30 | 72.1+1.5* |
| Brevenal 1.0 μg/ml | 9 | 30.8+2.6 |
| Brevenal 100 μg/ml | 3 | 36.3+1.7 |
| Brevenal 1.0 μg/ml 1 h before PbTx-2 10−8 M (Sigma) | 3 | 31.3+2.1 |
| PbTx-2 10−8 M (Sigma) 1 h before Brevenal 1.0 μg/ml | 3 | 33.5+0.3 |
| Brevenal 1.0 μg/ml 1 h before PbTx-2 10−8 M (UNCW) | 3 | 33.9+1.4 |
| PbTx-2 10−8 M (UNCW) 1 h before Brevenal 1.0 μg/ml | 3 | 40.3+1.9 |
| Brevenal 1.0 μg/ml 1 h before PbTx-9 10−8 M (Sigma) | 3 | 35.5+2.9 |
| PbTx-9 10−8 M Sigma 1 h before Brevenal 1.0 μg/ml | 3 | 40.1+2.4 |
| Brevenal 1.0 μg/ml 1 h before PbTx-3 10−8 M (UNCW) | 6 | 34.9+1.25 |
| PbTx-3 10−8 M (UNCW) 1 h before Brevenal 1.0 μg/ml | 3 | 42.4+0.75** |
| Brevenal 1.0 μg/ml simultaneously with PbTx-2 10−8 M (Sigma) | 3 | 27.4+1.2 |
| Brevenal 1.0 μg/ml simultaneously with PbTx-2 10−8 M (UNCW) | 3 | 49.2+7.1 |
Significantly different from the negative control, p<0.05.
Significantly different from brevenal 1.0 μg/ml, p<0.05.