. Author manuscript; available in PMC: 2009 Sep 1.

Published in final edited form as: Bioorg Med Chem. 2008 Jul 24;16(17):8090–8097. doi: 10.1016/j.bmc.2008.07.053

Table 1.

Kinetic constants of wild-type and CCPGCC-insertion PTPs assayed with pNPP

enzyme	k_cat (s^-1)	K_M (mM)	k_cat/K_M (mM^-1s^-1)

PTP1B	5.5±0.24	2.4±0.25	2.3±0.15
PTP1B-186	0.11±0.0021	0.94±0.042	0.12±0.0050

HePTP	3.1±0.045	6.9±0.19	0.45±0.014
HePTP-211	0.22±0.0081	4.4±0.24	0.049±0.00084

FAP-1	0.82±0.0036	0.94±0.032	0.87±0.026
FAP-1-2364	0.24±0.0033	3.8±0.10	0.062±0.0011

PTP-PEST	0.59±0.018	3.9±0.072	0.15±0.0057
PTP-PEST-204	0.081±0.0012	3.5±0.13	0.023±0.00061

PTPH1	5.2±0.18	0.49±0.038	11±0.47
PTPH1-816	5.3±0.28	0.74±0.064	7.1±0.24

PTPα	1.7±0.15	8.0±0.90	0.21±0.0052
PTPα-406	2.2±0.28	2.7±0.60	0.83±0.075