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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Cancer Res. 2008 Aug 1;68(15):6241–6250. doi: 10.1158/0008-5472.CAN-07-6849

Figure 4. Cytoskeletal reorganization and formation of actin stress fibers during the switch from dormancy to metastatic growth.

Figure 4

A) SCOM images (magnification x100) of lungs from mice injected with either D2A1-GFP (removed 1 or 3 weeks post-injection), D2.0R GFP (removed 4 or 12 weeks post-injection) MDA-MB-231-GFP (removed 2 weeks post-injection) or MCF-7-GFP cells (removed 9 weeks post-injection). Time points varied according to the growth properties of the cells. B) Frozen sections of lungs from mice injected with the above cells at the indicated time points stained for f-actin (red); confocal microscopy, white bar equals 20 microns. White arrowheads depict cortical actin staining; white arrows indicate f-actin stress fibers.